Rose Masterpol was born in New York and currently resides in Santa Fe, New Mexico. She received a B.F.A. from the California Institute of the Arts. Since a child, it was apparent that she would lead a life of creativity from music to drawing, sculpture, photography, and painting. Masterpol holds a graphic design degree from CalArts and has worked for many years in advertising agencies in Los Angeles as a creative director. 

She has been exhibiting regularly throughout California, Mexico, and the American west since the 1990s, including one-person exhibits in Los Angeles, Provincetown and Santa Fe. She has been published in many featured articles in blogs, newspapers, websites and magazines with a large collector base in the United States, China and England.